15-second LNP payload and ligand quantification
Quantify Payloads & Ligands in LNPs in Seconds, Not Hours
UV/Vis spectroscopy is a workhorse of life sciences for good reason — it's great for directly quantifying molecular concentrations. But it doesn't work when nanoparticles are present. Nanoparticles cause the light to scatter, which introduces big measurement errors and renders UV/Vis unusable.
Marama Labs' CloudSpec instrument — powered by Scatter-Free Absorption (SFA) technology — eliminates the interference caused by scattered light by design. CloudSpec's patented optical design enables accurate UV-based quantification of nucleic acids and ligands in lipid nanoparticle (LNP) samples, without needing to lyse LNPs or use fluorescent dyes.
Scatter-Free Absorption
Our patented SFA technology enables simple and effective use of accepted UV quantification methods by measuring the absorption spectrum without the scatter that clouds regular UV/Vis analysis.
Scatter inherent in biological samples - nanoparticles, cells, bacteria, etc., is avoided without any a priori knowledge of the particle size or makeup.
CloudSpec cuts through cloudiness for rapid and easy quantification and particle characterisation.
CloudSpec: Scatter-Free Analysis in Seconds
CloudSpec cuts through scatter making UV/Vis measurements of cloudy samples as easy (and reliable) as regular UV/Vis. If you want to quantify an analyte but couldn't because it was cloudy then CloudSpec is for you.
CloudSpec requires minimal sample prep - just a sample dilution - and a 15-second measurement, for fast, simple and precise sample analysis.
Scatter-Free Absorption
Our patented SFA technology enables simple and effective use of accepted UV quantification methods by measuring the absorption spectrum without the scatter that clouds regular UV/Vis analysis.
Scatter inherent in biological samples - nanoparticles, cells, bacteria, etc., is avoided without any a priori knowledge of the particle size or makeup.
CloudSpec cuts through cloudiness for rapid and easy quantification and particle characterisation.
Applications of CloudSpec
Just like regular UV/Vis, there are many applications for CloudSpec. If your sample scatters light, but you need a quantitative analysis in the UV or visible region, then CloudSpec will provide the answer.
Therapeutic particles <300nm in size, such as liposomes, LNPs, metal NPs, etc., are ideal as they scatter light significantly and are otherwise difficult to analyse non-destructively. Growth in bacteria and cells can be monitored to understand the underlying processes.
